What effects do Non-Benzodiazepines have on sleep?

What effects do Non-Benzodiazepines have on sleep?

• A. Increases REM and N1
• B. No change to sleep
• C. Decreases SL, WASO, N1, REM
• D. Increases sleep latency

Answer: (C)

Non-benzodiazepine hypnotics promote sleep by selectively enhancing GABA-A receptor activity at the BZ1 (omega-1) site, which favors quicker sleep onset and steadier sleep without the broad sedative effects of benzodiazepines. Because of this action, they shorten the time it takes to fall asleep (sleep latency) and reduce awakenings after sleep begins (WASO). They also tend to lessen the amount of time spent in the light sleep stage (N1) and can modestly reduce REM sleep. So, these drugs typically decrease sleep latency, WASO, N1, and REM, matching the option identified as correct. They do not increase sleep latency.

Non-benzodiazepine hypnotics promote sleep by selectively enhancing GABA-A receptor activity at the BZ1 (omega-1) site, which favors quicker sleep onset and steadier sleep without the broad sedative effects of benzodiazepines. Because of this action, they shorten the time it takes to fall asleep (sleep latency) and reduce awakenings after sleep begins (WASO). They also tend to lessen the amount of time spent in the light sleep stage (N1) and can modestly reduce REM sleep. So, these drugs typically decrease sleep latency, WASO, N1, and REM, matching the option identified as correct. They do not increase sleep latency.