Clonazepam increases which sleep parameters?

Clonazepam increases which sleep parameters?

• A. TST, N1, N2 and arousals
• B. REM increases
• C. SWS increases
• D. Wakefulness increases

Answer: (A)

Clonazepam, a benzodiazepine, enhances GABA-A activity to promote sleep. Its effect on sleep architecture is to increase total sleep time and more time spent in lighter non-REM stages (N1 and N2), while REM and deep sleep (SWS) are typically reduced. It can also lead to more brief awakenings or arousals as the sleep becomes more fragmented. Therefore, the pattern you’d expect with clonazepam is longer total sleep time, more time in N1 and N2, and increased arousals, not more REM, not more deep sleep, and not more wakefulness during the night. That’s why the best answer lists TST, N1, N2, and arousals.

Clonazepam, a benzodiazepine, enhances GABA-A activity to promote sleep. Its effect on sleep architecture is to increase total sleep time and more time spent in lighter non-REM stages (N1 and N2), while REM and deep sleep (SWS) are typically reduced. It can also lead to more brief awakenings or arousals as the sleep becomes more fragmented. Therefore, the pattern you’d expect with clonazepam is longer total sleep time, more time in N1 and N2, and increased arousals, not more REM, not more deep sleep, and not more wakefulness during the night. That’s why the best answer lists TST, N1, N2, and arousals.